The Efficacy of L-cysteine in Prevention of Cluster Headache

• Status: Completed
• Trial end date: 2020-10-14
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to validate the novel hypothesis that daily use of L-cysteine (Acetium® capsules) is an effective means to decrease the frequency of (or completely abort) the attacks of cluster headache.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Biohit Oyj
• Collaborator: The Finnish Funding Agency for Technology and Innovation (TEKES)

Criteria

Inclusion Criteria:

• 18-65 years male/female

• episodic and chronic cluster headache

• the subjects should report cluster headache attacks with the frequency from one every second day up to five per day. The individual attacks should last from 15 minutes to 3h.

Exclusion Criteria:

• patients who meet the International Classification of Headache Disorders II criteria for medication overuse

• patients who have taken anti-psychotics or anti-depressant medications during the previous 3 months

• patients who abuse alcohol or other drugs

• potentially fertile and sexually active women who do not practise contraception

• other acute or chronic pain disorders

• severe psychiatric disease

• infections

• malignancy

• short life expectancy

• cardiovascular disease

• cerebrovascular disease

• uncontrolled hypertension

• degenerative central nervous system diseases

• pregnant and lactating women

• regular users of Acetium capsules for other indications

• renal dysfunction or cystinuria