The Efficacy of Local Infiltration Analgesia for Postoperative Pain Management After Total Knee Arthroplasty

• Status: Recruiting
• Trial end date: 2021-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This prospective, double-blinded, randomized controlled study evaluates the effects of peripheral nerve blocks with and without local infiltration analgesia for postoperative pain management after primary total knee arthroplasty. There are no any studies that show the demand for local infiltration analgesia when together peripheral nerve blocks are performed. Patients undergoing primary total knee arthroplasty will be randomly assigned to receive local infiltration analgesia with or without (placebo group) local anesthetic. All patients will receive peripheral nerve blocks for postoperative analgesia: femoral triangle and distal adductor canal blocks. Comparison of these two groups of patients will be based on the effects on postoperative pain control, the extent of motor blockade, the ability of early leg motion and ambulation, patients satisfaction rates over the time of clinical recovery.

Consequently, the investigators hypothesized that peripheral nerve blocks (femoral triangle and distal adductor canal blocks) with and without local infiltration analgesia provide similar postoperative pain relieving effects and the ability of early mobilization after total knee arthroplasty.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Lithuanian University of Health Sciences
• Treatments: Anesthetics; Anesthetics, Local; Bupivacaine; Epinephrine; Epinephryl borate; Pharmaceutical Solutions; Racepinephrine

Criteria

Inclusion Criteria:

• Patients undergoing primary unilateral total knee arthroplasty under spinal anaesthesia;

• Age 18 - 90 years;

• Patients conformed to American Society of Anaesthesiologists (ASA) physical status I-III in preoperative assessment;

• Ability to follow the study protocol.

Exclusion Criteria:

• Inability or refusal to follow the study protocol.

• American Society of Anesthesiologists (ASA) physical status classification of IV or higher.

• Coagulopathy.

• Pre-exiting lower extremity neuromuscular disorders.

• Local infection over injection site.

• Allergy or contraindications to the drugs used in the study (local anesthetics, NSAIDs, opioids).

• Chronic opioid use.

• Other type of anesthesia.