The Efficacy of Lopinavir Plus Ritonavir and Arbidol Against Novel Coronavirus Infection

• Status: Completed
• Trial end date: 2020-05-31
• Target enrollment: 0
• Participant gender: All

Summary

The study explores the efficacy of lopinavir plus ritonavir and arbidol in treating with novel coronavirus infection. As a result this study would provide evidence for the clinical usage of these drugs in the future .

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Guangzhou 8th People's Hospital
• Treatments: Lopinavir; Ritonavir

Criteria

Inclusion Criteria:

• In sputum, throat swab, lower respiratory tract secretion, blood and other samples, the nucleic acid of the novel coronavirus was positive, or the sequencing of the virus gene was highly homologous with the known novel coronavirus

• Age is between 18-80 years old, the weight is more than 30kg, and there is no limit for men and women

• The following conditions were met: creatinine ≤ 110 umol / L, creatinine clearance rate (EGFR) ≥ 60 ml / min / 1.73m2, AST and ALT ≤ 5 × ULN, TBIL ≤ 2 × ULN;

• The subjects should fully understand the purpose, nature, method and possible reaction of the study, voluntarily participate in the study and sign the informed consent.

Exclusion Criteria:

• Have a clear history of lopinavir or ritonavir or arbidol allergy

• Severe nausea, vomiting, diarrhea and other clinical manifestations affect the oral or absorption of the drugs

• At the same time, take drugs that may interact with lopinavir or ritonavir or arbidol

• Patients with serious underlying diseases, including but not limited to heart disease (including history of angina pectoris or coronary heart disease or myocardial infarction, atrioventricular block), lung, kidney, liver malfunction and mental diseases that cannot be treated together

• ancreatitis or hemophilia

• Pregnant and lactating women

• Suspected or confirmed history of alcohol and drug abuse

• Participated in other drug trials in the past month

• The researchers judged that patients were not suitable for the study