The Efficacy of N-acetylcysteine on Alleviating Symptom Caused by Lugol Chromoendoscopy
Status:
Recruiting
Trial end date:
2021-05-31
Target enrollment:
Participant gender:
Summary
Lugol chromoendoscopy is essential in detecting and characterizing squamous cell carcinoma of
esophagus. Esophageal irritating symptom has been reported as an common adverse event, which
could be alleviated by sodium thiosulfate solutions. However, sodium thiosulfate was not
widely available. N-acetylcysteine has been previously used as a mucolytic reagent, we
propose that it may also be used to alleviate irritating symptoms caused by Lugo's
chromoendoscopy. A prospective, non-inferior, randomized double-blind clinical trial was
designed to study the efficacy of N-acetylcysteine solutions in relieving esophageal
discomfort .