The Efficacy of PRP Combined With Exercise to Treat Knee Osteoarthritisq
Status:
Completed
Trial end date:
2021-10-01
Target enrollment:
Participant gender:
Summary
Objective. In this study, we aimed to investigate the efficacy of combined a single
platelet-rich plasma (PRP) and physical exercise (leg swing and quadriceps strengthening
exercise) versus PRP and hyaluronic acid (HA) combination therapy. Methods. One hundred and
six patients with grade Ⅱ-Ⅲ Knee osteoarthritis (KOA) according to the Kellgren-Lawrence
classification were randomly divided into intra-articular injection of PRP combined with leg
swing and quadriceps strengthening exercise (group A) and intra-articular combination
injections of PRP and HA (group B). Patients in group A received twice intra-articular
injection of PRP (2 ml, 2 weeks apart) and regular leg swing and quadriceps strengthening
exercise for 3 months. Patients in group B received twice intra-articular combination
injections of PRP (2 ml) and HA (2 ml) every 2 weeks. The primary outcome measures were
Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities (WOMAC) score. The
second outcomes included single leg stance test (SLS) and functional activity by 2 minutes
walking test (2MWT) and time up and go test (TUGT). All outcomes were evaluated at baseline
and after 1,3,6, and 12 months.