The Efficacy of PRP Combined With Exercise to Treat Knee Osteoarthritisq

• Status: Completed
• Trial end date: 2021-10-01
• Target enrollment: 0
• Participant gender: All

Summary

Objective. In this study, we aimed to investigate the efficacy of combined a single platelet-rich plasma (PRP) and physical exercise (leg swing and quadriceps strengthening exercise) versus PRP and hyaluronic acid (HA) combination therapy. Methods. One hundred and six patients with grade Ⅱ-Ⅲ Knee osteoarthritis (KOA) according to the Kellgren-Lawrence classification were randomly divided into intra-articular injection of PRP combined with leg swing and quadriceps strengthening exercise (group A) and intra-articular combination injections of PRP and HA (group B). Patients in group A received twice intra-articular injection of PRP (2 ml, 2 weeks apart) and regular leg swing and quadriceps strengthening exercise for 3 months. Patients in group B received twice intra-articular combination injections of PRP (2 ml) and HA (2 ml) every 2 weeks. The primary outcome measures were Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities (WOMAC) score. The second outcomes included single leg stance test (SLS) and functional activity by 2 minutes walking test (2MWT) and time up and go test (TUGT). All outcomes were evaluated at baseline and after 1,3,6, and 12 months.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hebei Medical University Third Hospital

Criteria

Inclusion Criteria:

• 1) patients aged ≥ 45 years old; 2) KOA was diagnosed according to the American College of Rheumatology Classification Criteria; 3) patients with the Kellgren-Lawrence grade (K-L grade) for KOA of Ⅰ-Ⅲ; 4) a history of symptoms more than three month, and patients with independent mobility.

Exclusion Criteria:

• 1) lower limb axial deviation large than 5° (valgus and varus knee); 2) patients with diabetes mellitus, sever cardiovascular disease, immunosuppressive status, mental illness or other diseases than might affect the results; 3) injections or other invasive treatments into the lower extremities were used in the past three months; 4) patients willing to follow the doctor's recommendation for exercise training; 5) patients with previous knee fracture or malignancy; 6) patients with a previous history of hip or knee joint surgery; 7) patients participating in hip or knee muscle strengthening in the past 3 months; and 8) patients did not complete the intervention strategies or regular follow-up.