The Efficacy of Papaverine to Prevent Radial Artery Spasm During Transradial Cerebral Angiography

• Status: Not yet recruiting
• Trial end date: 2023-10-30
• Target enrollment: 0
• Participant gender: All

Summary

Rationale:Papaverine is effective on radial artery spasm during transradial cerebral angiography.

Purpose: This multicenter, randomized, placebo-controlled, double blind, phase 2b trial aims to investigate the effect and safety of papaverine in treating radial artery spasm during transradial cerebral angiography.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
• Treatments: Papaverine

Criteria

Inclusion Criteria:

1. All patients scheduled for cerebral angiography will be eligible for screening.

2. Participant is willing and is able to give informed consent for participating in the trial.

3. Male or Female, aged 18 years or above.

Exclusion Criteria:

1. Any patient with negative modified Allen test

2. Altered liver function

3. atrioventricular heart block III degree

4. Suspected or confirmed cerebral hemorrhage patients

5. Hemodynamic Instability : systolic pressure < 100 mmHg, heart rate > 100 bpm, tachycardia uncontrollable.

6. Patients with cerebral edema and increased intracranial pressure within 24 hours to 2 weeks after stroke

7. Coronary artery bypass grafting(CABG) operation history and whose right radial artery is missing as a "bridge vessel"

8. Severe skin musculoskeletal malformation of forearm or failure to complete radial artery puncture and sheath placement for other reasons

9. Hypersensitivity or contraindication to papaverine

10. Hypersensitivity or contraindication to nitroglycerine

11. Glaucomatous patients

12. Parkinson's disease patients

13. Women who are suspected or known to be pregnant or breastfeeding