The Efficacy of Penile Rehabilitation Using Udenafil After Total Mesorectal Excision of Rectal Cancer

• Status: Completed
• Trial end date: 2013-10-01
• Target enrollment: 0
• Participant gender: Male

Summary

Sexual dysfunctions are well-recognized complications after rectal cancer surgery. Damage to the pelvic plexus and pelvic splanchnic nerves results in ejaculatory dysfunction. The purpose of this study is to evaluate the efficacy of Udenafil(Zydena®, Dong-A Pharmaceutical co., Ltd, Seoul, Korea) in penile rehabilitation for patients who undertake total mesorectal excision.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Kyungpook National University; Kyungpook National University Hospital
• Treatments: Udenafil

Criteria

Inclusion Criteria:

• Age : 20-65

• Rectal cancer within 15cm from anal verge

• Patients with more than 5 points decreased IIEF-5 after operation

• Patients with sexual activity

Exclusion Criteria:

• Preoperative IIEF-5 : ≤14

• Recent MI, CVA, nitrate medication

• Severe cardiovascular disease, psychiatric disease

• Severe hepatic dysfunction (GOT, GPT ≥100IU/L)

• Renal dysfunction (Cr ≥2mg/dl)