The Efficacy of Postoperative Analgesia of Gabapentin Plus Nefopam in the Spinal Surgery
Status:
Completed
Trial end date:
2021-05-31
Target enrollment:
Participant gender:
Summary
The acute pain after spinal surgery is serious. The most pain is during 24 hours after
surgery. The multimodal therapy is a method which is applied to treat the postoperative pain.
Morphine is main analgesic to treat postoperative pain. However, some the side-effects can
occur to patients and there are associate with dosage. So, some analgesics usually combinate
with morphine to postoperative analgesia, include gabapentin, celecoxib, ketamine, ...
Nefopam is a central analgesic. There are effect prevent hyperalgesia. The effect of the
combination of gabapentin with nefopam to postoperative analgesia in spinal surgery hasn't
been reported yet.
The gabapentin oral with 600 mg combine with continuously intravenous nefopam with 65
µg/kg/hour during 24 hours after spinal surgery whether to increase the effect of
postoperative analgesia.
The investigators hypothesized that the gabapentin oral with 600 mg combine with continuously
intravenous nefopam with 65 µg/kg/hour during 24 hours after spinal surgery can decrease 40%
of the consumption of morphine during 24 hours.