The Efficacy of Pre-procedural Mouth Rinses on COVID-19 Saliva Viral Load

• Status: Recruiting
• Trial end date: 2021-06-30
• Target enrollment: 0
• Participant gender: All

Summary

Preoperative antiseptic mouth rinses have been widely used as a standard protocol before routine dental treatment reduces oral microorganism counts. During dental procedures, aerosolized microorganisms contaminate the dental environment and nearby surfaces and remain suspended for 4 hours. Thus, the reduction in the number of aerosolized microorganisms by pre-procedural rinsing may reduce cross-contamination between dentists, office personnel, and patients. Recent reviews have advocated the use of preoperative rinsing to control and reduce the risk of SARS-CoV-2 transmission. However, no clinical studies have been done yet to support the effectiveness of any pre-procedural oral rinses against SARS-CoV-2. The proposed study will mitigate the spread of COVID-19 disease in dental health care facilities and ensure the patients' good health and healthcare workers. The purpose of this clinical trial is to determine and compare the effectiveness of four commercially available, pre-procedural mouth rinses versus distilled water on viral load of SARS-CoV-2 found in the saliva of COVID-19 positive patients and to measure the pre-rinsing viral load with the post-rinsing at three-time points.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: King Abdulaziz University
• Treatments: Cetylpyridinium; Eusol; Hydrogen Peroxide; Listerine; Povidone; Povidone-Iodine; Sodium Fluoride; Sodium Hypochlorite

Criteria

Inclusion Criteria:

1. Adults age 18 years or older presented to TETAMMAN clinics, Jeddah, Saudi Arabia.

2. COVID-19 positive patients confirmed by RT-PCR and within two days of oral or nasopharyngeal swabs

3. Asymptomatic or within seven days of the onset of symptoms.

4. Has the ability to rinse and expectorate.

Exclusion Criteria:

1. Participants who started hydroxychloroquine treatment or on antibiotics.

2. Known allergy to one of the constituents of the mouth rinse

3. Thyroid disease or on current radioactive iodine treatment

4. Pregnant or breastfeeding women

5. Lithium therapy

6. Participants on corticosteroid medication

7. Has Sjogren's syndrome

8. Immune-compromised (HIV/AIDS, cancer, organ transplant, or immunosuppressive medications)

9. History of radiotherapy or chemotherapy

10. Use of mouthwash or MISWAK before presented to TETAMMAN clinics