The Estrogen Impact on Overactive Bladder Syndrome: Female Pelvic Floor Microbiomes and Antimicrobial Peptides
Status:
Completed
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
The medical field is beginning to adopt treatments that alter an individual's microbiome to
improve patient health; however, this approach has not been adopted for treatment of lower
urinary tract symptoms (LUTS). Here, the investigators propose the first step in development
of such a therapy. If the investigators hypothesis is correct, the investigators could change
the first line of treatment for hypoestrogenic women and develop future therapies that
modulate bacteria in the bladder to improve not only LUTS but also treatment response. This
could lead to the first treatment for lower urinary disorders that incorporates a person's
individual microbiome.