The Gender-Sex Hormone Interface With Craving & Stress-Related Changes in Smoking
Status:
Completed
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
The purpose of the overall parent study is to determine the impact of gender and hormones
(estradiol, progesterone, testosterone and cortisol) on responses to stress and smoking cues
presented in daily, "real-world" cue presentations compared to a final cue session in a lab.
In addition, in the portion of the study that incorporates clinical trials elements and is
reported here, the study will examine the impact of a single dose of oxytocin (chemical
produced in the body) versus placebo (inactive substance) on reactivity to a stress procedure
(Trier Social Stress Task) in smokers.
The overall parent study involves a cue presentation technology known as "CREMA" (Cue
Reactivity Ecologic Momentary Assessment) which delivers four daily cue presentations to you
on a handheld device during your everyday routine. Additionally, the study involves daily
collection of saliva samples for hormonal testing. These daily procedures will provide
information about the role of cues and hormones in daily life. The clinical trial portion of
the study (reported here) consists of measures collected within the laboratory.