The ImPact of Trimetazidine on MicrOcirculation After Stenting for Stable Coronary Artery Disease
Status:
Unknown status
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
The study should enrol 50 patients with stable coronary artery disease scheduled for elective
percutaneous coronary intervention of single, de novo lesion of native coronary artery.
Patients will be randomized to orally given trimetazidine on top of standard medical therapy
for stable coronary artery disease versus standard therapy only. The randomization will begin
48 hrs before intervention. Index of microcirculatory resistance (IMR) will be measured by
thermodilution method using coronary pressure and temperature wire before and after stent
implantation. Echocardiography will be performed before intervention and within 30 minutes
after intervention. Patients will be followed clinically for a period of one year.