The Immunomodulatory Effects of Oral Nanocurcumin in Multiple Sclerosis Patients
Status:
Completed
Trial end date:
2017-11-07
Target enrollment:
Participant gender:
Summary
Multiple sclerosis is the most common autoimmune disease of the central nervous system, most
ranging in age from 40-20 years of age is associated with neurons inflammation and
demyelination. Increasing aggressive activities of Th17 and Th1 cells that their function is
to secrete proinflammatory cytokines and decreasing the number and activity of regulatory T
cells, which normally leads to controlling inflammation, are seen in these patients.Many
studies have carried out to assess the prevalence of Tregs and Th17 in autoimmune disorders
such as MS. The Treg /Th17 functional balance is necessary for the impediment of autoimmune
and inflammatory diseases by preventing harmful injury to the host and increasing effective
immune responses. miRNAs have been shown to play a pivotal role in the pathogenesis of
various diseases including autoimmune or auto-inflammatory diseases. Curcumin, the active
principle constituent of turmeric, is proved to be capable of regulating cellular responses
and the growth of different cell types in the immune system such as B cells, T cells,
macrophages, dendritic cells and natural killer cells. Curcumin has a combination of
activities such as anti-inflammatory, antioxidant, anti-proliferation, anti-invasive, and can
used in the treatment of Alzheimer's, Parkinson's, Multiple sclerosis, Cardiovascular
disease, Bacterial diseases and Arthritis. The solubility of curcumin in nanomicelles
spherical water increases to more than 100 thousand times, which significantly enhances the
absorption of curcumin. The present study aimed at investigating the effects of nanocurcumin
on the frequency of Treg and Th17 cells, expression levels of their associated transcription
factors and cytokines, secretion levels of their associated cytokines and also related miRNAs
expression levels in peripheral blood of patients with MS.
.
Phase:
Phase 2
Details
Lead Sponsor:
SCARM Institute, Tabriz, Iran Tabriz University of Medical Sciences