The Impact of Caffeine on Brachial Endothelial Function in Healthy Subjects and in Patients With Ischemic Heart Disease
Status:
Completed
Trial end date:
2010-01-01
Target enrollment:
Participant gender:
Summary
Prior work (Chris, M. et al, Clinical Science 2005; 109, 55-60) has demonstrated that
drinking a cup of coffee (80-100 mg of caffeine) an hour before endothelium-dependent FMD
(flow-mediated dilatation) of the brachial artery, effects endothelial function in healthy
adults subjects.
This effect might be attributed to caffeine, given that decaffeinated coffee (<2 mg of
caffeine) was not associated with any change in endothelial performance.
In the current study we intend to further examine the impact of caffeine on brachial
endothelial function among healthy subjects & in patients with proven ischemic heart disease.