The Impact of Carbon Monoxide and Altitude on Vascular Function

• Status: Recruiting
• Trial end date: 2021-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The CarMA (Carbon Monoxide and Altitude) Study aims to observe the vascular effects of carbon monoxide exposure at low and high altitudes.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alberta
• Treatments: Carbon Monoxide; Nitroprusside; Oxymetazoline; Phenylephrine

Criteria

Inclusion Criteria:

• Between the ages of 18-50 years

• No medical history of cardiovascular, respiratory, nervous system, or metabolic disease.

• Women must be pre-menopausal.

Exclusion Criteria:

• Participants with any known cardiovascular, respiratory, nervous system, or metabolic disease.

• Having travelled above 2,000m within 1 month of testing at low and high altitude.

• Women who are pregnant, confirmed by a pregnancy test.

• Women who are post-menopausal.

• Participants that are classified as obese (body mass index > 30 kg/m2).

• Participants who are current daily smokers.

• Participants that are currently taking monoamine (MAO) inhibitors, or tricyclic antidepressants.