The Impact of Gall Bladder Emptying and Bile Acids on the Human GLP-1-secretion
Status:
Completed
Trial end date:
2014-04-01
Target enrollment:
Participant gender:
Summary
The last couple of years it has been shown that bile acids not only acts as simple
emulsifiers of fat, but constitutes a complex metabolic integrator which not only have an
influence on fat digestion and lipid metabolism, but also modulates the energy expenditure in
(brown) adipose tissue and muscle tissue. This action is due to stimulation of the receptor
TGR5 by bile acids. Recently scientists have discovered that this receptor in rodents is also
expressed on the surface of intestinal L-cells (which normally secrets Glucagon-Like
Peptide-1 (GLP-1) in response to nutrient stimulation). The stimulation of this receptor has
shown a GLP-1 secretion from the intestinal cells which is interesting since GLP-1 has a
central role in maintaining normal glucose tolerance and thus blood sugar. Given the above,
bile acids has an important impact on intestinal GLP-1 secretion. Whether these scientific
findings can be proven in human beings is uncertain.
The primary hypothesis is that stimulating gall bladder emptying via Cholecystokinin (CCK) in
healthy subjects will result in a significant GLP-1 response. We also hypothesize that adding
orally Metformin or a sequestrant ("a bile acid binder") will further enhance this GLP-1
response.
Phase:
N/A
Details
Lead Sponsor:
Filip Krag Knop
Collaborator:
University of Copenhagen
Treatments:
Acetaminophen Bile Acids and Salts Cholecystokinin Colesevelam Hydrochloride Metformin