The Impact of Grapefruit Juice on the Response to Clopidogrel

• Status: Completed
• Trial end date: 2011-07-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will measure the percentage of platelet aggregation inhibition with a loading dose of clopidogrel (300 mg) using the VerifyNow Assay System in healthy volunteers who have drank 11 oz of grapefruit juice. It will also measure the percentage of platelet aggregation inhibition with a maintenance dose of clopidogrel (75 mg/day) using the VerifyNow Assay System in healthy volunteers who have drank 11 oz grapefruit juice daily.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Creighton University
• Treatments: Clopidogrel; Ticlopidine

Criteria

Inclusion Criteria:

• Ages 19-40

• Health status confirmed by medical history and physical examination and laboratory analysis

Exclusion Criteria:

• Pregnancy

• Taking routine prescription or over-the-counter prescriptions

• Taken over-the-counter analgesic/anti-inflammatory medication within two weeks of study participation

• Recently had grapefruit juice or regularly drinks grapefruit juice