The Impact of Intravenous Anaesthesia on Angiogenesis in Patients With Breast Cancer (TIVA/TCI-BC)

• Status: Completed
• Trial end date: 2019-09-01
• Target enrollment: 0
• Participant gender: Female

Summary

Because neoplastic disease is one of the leading causes of death worldwide and breast cancer is one of the most frequent neoplasia among women, the possibility of influencing the evolution of patients starting from the moment of surgical intervention using a perianesthesic intervention is a scientific topic of high interest. The study will compare two anesthetic techniques and their efficiency in lowering the factors that can favorize the dissemination of neoplasia and their role in the prevention of postoperative pain. The serum level of vascular endothelial growth factor A (VEGF-A) will be determined before and after the surgical intervention after using two different types of anesthesia (inhalational and intravenous), and the immunohistochemical expression of vascular endothelial growth factor receptors (VEGFR) will be determined on the excised tissue. For the two different types of anesthesia a continuous infusion of lidocaine 1% will be associated. The study will compare the short-term and long term-outcome of the patients assigned the two different types of anesthesia and their immediate postoperative evolution .

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy
• Collaborator: Prof. Dr. I. Chiricuta Institute of Oncology
• Treatments: Acetaminophen; Anesthetics; Atropine; Lidocaine; Neostigmine; Sevoflurane; Tramadol

Criteria

Inclusion Criteria:

• diagnosis of breast cancer

• ASA risk class I-III

• no metastatic disease

Exclusion Criteria:

• hepatic, pulmonary metastasis

• type I and II diabetes

• rheumatoid arthritis

• osteoarthritis

• ischemic cardiovascular disease (history of myocardial infarction, angina)

• peripheral vascular disease

• endometriosis

• allergies to lidocaine, fentanyl, propofol, sevoflurane, atracurium, midazolam, acetaminophen, tramadol

• neuropsychiatric disorders

• incapacity of understanding the study

• refusal of participation