The Impact of Intravenous Vitamin C Combined With Nerve Blocks on Postoperative Pain and Recovery After Total Knee Arthroplasty

• Status: Not yet recruiting
• Trial end date: 2023-06-09
• Target enrollment: 0
• Participant gender: All

Summary

The aim of this prospective randomized-control study was to evaluate the impact of a single high-dose intravenous vitamin C added to ultrasound-guided blocks at induction on postoperative pain, sngception and early functional rehabilitation of the knee joint in patients under-going total knee arthroplasty.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Chimei Medical Center
• Treatments: Ascorbic Acid

Criteria

Inclusion Criteria:

1. Physical status according to American Society of Anesthesiologists (ASA) I-III

2. Patients scheduled for total knee arthroplasty

3. Age ranging from 50 to 80 years old

Exclusion Criteria:

1. Previous operation on the same knee

2. Allergy or intolerance to one of the study medications

3. Coagulopathy

4. Having lower limbs neuropathy

5. End-organ failure (CKD stage V or VI, NYHA III or IV)

6. BMI > 35

7. Chronic opioid use or drug abuser

8. Difficulty in communication (Impaired mental status)

9. Hyperuricemia or Glucose-6-phosphate dehydrogenase deficiency patient