The Impact of Ketamine on Postoperative Cognitive Dysfunction, Delirium, and Renal Dysfunction
Status:
Completed
Trial end date:
2020-12-01
Target enrollment:
Participant gender:
Summary
Ketamine is a commonly used anesthetic medication which is used for induction of anesthesia
as well as as an analgesic. It has been shown to have anti-inflammatory properties which may
decrease post-operative complications following cardiac surgery with cardiopulmonary bypass
that are thought to associated with inflammation. Some studies have shown that ketamine does
decrease these complications when compared with anesthetics that are not commonly used in our
cardiac anesthesiology practice. Propofol is another commonly used anesthetic medication
which is used for induction of anesthesia. Ketamine has not been compared with propofol for
potential to reduce post-operative complications associated with the inflammatory process.
This study aims to see if ketamine will reduce the incidence of cognitive dysfunction,
delirium, and renal dysfunction in comparison with propofol. In addition, the hemodynamic
impact of ketamine compared propofol will be investigated.