The Impact of Prednisone on Semen Parameters and Pregnancy Rates Post Vasectomy Reversal

• Status: Recruiting
• Trial end date: 2026-02-01
• Target enrollment: 0
• Participant gender: Male

Summary

1. Determine impact of prednisone on semen parameters post vasectomy reversal (evaluated both using prednisone as a combined cohort as well as via 3 separate protocols).

2. Determine impact of prednisone on pregnancy rates post vasectomy reversal (evaluated both using prednisone as a combined cohort as well as via 3 separate protocols).

3. Assess adverse events with prednisone utilization

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Charitable Union for the Research and Education of Peyronie's Disease
• Treatments: Prednisone

Criteria

Inclusion Criteria:

• Men undergoing a first-time vasectomy reversal at the Male Fertility and Peyronie's Clinic

• 18-65 years of age

• Current sexual partner with desire to achieve pregnancy immediately

• Intent of reversal to restore fertility

• Partner <36 years of age

• Partner with no known fertility issues

• Prior history of paternity

Exclusion Criteria:

• Current corticosteroid use

• Prior vasectomy reversal

• Prior chemotherapy

• Testosterone use within 1 year of the vasectomy reversal

• Solitary testicle

• History of diabetes mellitus

• History of systemic fungal infection

• Hypertension

• Any degree of diagnosed renal insufficiency

• Partner on birth control within past 3 months