The Impact of Renin-angiotensin System on Brain Activation During Hypoglycaemia in Healthy Men, a PET Study
Status:
Completed
Trial end date:
2008-02-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to evaluate the cerebral blood flow in subjects with high and
low activity in the renin-angiotensin system (RAS).The renin-angiotensin system is a hormone
system which is involved in the regulation of the blood pressure. Earlier studies have shown
that high RAS activity is associated with a more pronounced cognitive impairment during
hypoglycaemia compared to low RAS activity in both type 1 diabetic patients and healthy
volunteers. We intend to examine brain activity by oxygen-15 labelled water-PET scanning
during hypoglycaemia in response to cognitive function testing in 20 healthy male volunteers
with high and low RAS activity, respectively