The Impact of Treating Minor Uterine Cavity Abnormalities Diagnosed by Office Hysteroscopy in Unselected In Vitro Fertilization (IVF) Cases

• Status: Terminated
• Trial end date: 2009-03-01
• Target enrollment: 0
• Participant gender: Female

Summary

This is a comparative, controlled trial to evaluate the impact of treating undetected, asymptomatic, predefined minor uterine cavity abnormalities on the success of IVF treatment.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: UMC Utrecht
• Collaborator: AZ-VUB
• Treatments: Doxycycline

Criteria

Inclusion Criteria:

• Normal Transvaginal Ultrasound

• No prior hysteroscopy

• Regular menstrual cycle

• Single embryo transfer

• BMI between 18 and 29

• Presence of both ovaries

• Primary or secondary infertility

• Women indicated for a first IVF/ICSI cycle

Exclusion Criteria:

• Recurrent miscarriage

• Prior hysteroscopic treatments

• Endometriosis > AFS Stage II

• Meno-metrorrhagia (defined as any intermenstrual loss of blood)

• Submucosal/Intracavitary Fibroids taking more than 50% of the cavity

• Hydrosalpinx

• FSH/LH > 12IU/L on day 3

• Polyps taking more than 50% of the cavity

• Severe adhesions > grade II