The Improving Effect of Autologous Stromal Vascular Fraction (SVF) in Adipose Tissue on Skin Grafting

• Status: Unknown status
• Trial end date: 2016-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to observe whether the transplantation of autologous stromal vascular fraction (SVF) in adipose tissue is safe and its effect on improving the texture and contracture of skin grafting.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Shanghai Jiao Tong University School of Medicine
• Collaborators: Guangzhou General Hospital of Guangzhou Military Command; Second Affiliated Hospital of Suzhou University; The First People's Hospital of Zhaoqing City; West China Hospital; Wuhan Third Hospital

Criteria

Inclusion Criteria:

• With symmetrical scar or soft tissue deficiencies requiring skin graft therapy.

• Age of 3 to 70.

• Have no underlying disease except skin scar deformity.

• Have enough healthy donor site skin for both sides of receiving area.

Exclusion Criteria:

• Not fit for skin graft treatment;

• Evidence of infection, ischemia, ulcer or other pathological changes within the targeting area which defined as not suitable for skin grafting; or history of delayed healing, radiational therapy;

• Significant renal, cardiovascular, hepatic and psychiatric diseases;

• Significant medical diseases or infection (including but not limited to the carrier of hepatitis B virus or HIV);

• BMI >30;

• Alcohol abuse

• History of any hematological disease, including leukopenia , thrombocytopenia, or thrombocytosis;

• Evidence of malignant diseases or unwillingness to participate.