The Influence of Amitriptyline on Learning in a Visual Discrimination Task

• Status: Completed
• Trial end date: 2009-05-01
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to determine whether 75 mg amitriptyline affect the sleep dependent consolidation of procedural memory (visual discrimination task, Karni-Sagi-paradigm).

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Dieter Kunz, MD
• Treatments: Amitriptyline; Amitriptyline, perphenazine drug combination

Criteria

Inclusion Criteria:

• male gender

• age 18 through 40 years

• ability to communicate effectively in German

Exclusion Criteria:

• shift work within the past 24 months

• any sleep disorder as measured by the Pittsburgh Sleep Quality Index

• irregular sleep/wake patterns or extreme chronotype as measured by the Morningness-Eveningness Questionnaire

• history of any neurologic or psychiatric disorders

• regular medication intake within the past four weeks

• contraindications for amitriptyline

• abnormal electrocardiogram (ECG)