The Influence of Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on Renal Function in Patients Undergoing Non-emergent Coronary Angiography

• Status: Completed
• Trial end date: 2010-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of the current study is to evaluate prospectively whether concomitant administration of RAAS blockers (namely ACE-I and ARBs') influence the change in estimated GFR (eGFR) after administration of contrast media in patients undergoing non-emergent coronary angiography.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Soroka University Medical Center
• Treatments: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors

Criteria

Inclusion Criteria:

• 1. Age>18 years

• 2. Subjects on chronic therapy with ACE-I and/or ARBs' (confirmed by electronic records in their medical file)

• 3. Subjects planned to undergo non-emergent coronary angiography.

• 4. Signed informed consent

Exclusion Criteria:

• 1. eGFR<30 ml/min at baseline

• 2. Chronic utilization of NSAIDS and Cox-2 selective inhibitors

• 3. Chronic treatment with mineralocorticosteroid receptor blocker

• 4. Systolic blood pressure<90 mmHg

• 5. Planned staged (repeated) procedure within 48 hours

• 6. Administration of contrast within 14 days prior to the enrollment

• 7. contraindication to stop ACE-I or ARB'S