The Influence of Atropine on Choroidal Thickness

• Status: Completed
• Trial end date: 2017-11-20
• Target enrollment: 0
• Participant gender: All

Summary

Atropine eye drops are increasingly prescribed for the management of progressive myopia or short-sightedness. A previous study suggested that the back of the eye or choroid may be a part of the mechanism by which it induces its effects.

The aim of this study is to characterize the effects of atropine on choroidal thickness and the influence of time of administration (am vs pm). It is hypothesized that the atropine's effect on choroidal thickness will vary with baseline thickness related to diurnal rhythm, where thicker baseline thickness will show a reduced choroidal response.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: State University of New York College of Optometry
• Collaborator: The University of New South Wales
• Treatments: Atropine; Ophthalmic Solutions

Criteria

Inclusion Criteria:

• Good general and ocular health

• Soft contact lens wearers to cease lens wear for at least 24 hours

• No previous rigid gas permeable lens wear

Exclusion Criteria:

• History of ocular surgery, including refractive surgery

• Amblyopia

• Use of ocular medications

• Known allergies or sensitivity to atropine

• Pregnant, plan to become pregnant, or are breastfeeding

• Taking monoamine oxidase inhibitors (MAOIs)