The Influence of Inhaled Adrenalin Versus Decongestant as a Local Nasal Treatment in Bronchiolitis

• Status: Completed
• Trial end date: 2005-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This was a randomized, double blinded, controlled trial. The aim of the study was to compare xylometazoline HCL nasal drops to inhalation of epinephrine as a treatment for bronchiolitis.

The study hypothesis is:xylometazoline HCL nasal drops treatment is good as epinephrine inhalation for treatment of bronchiolitis.

Signed informed consent was obtained from a parent of each child. And the human ethics committee of our hospital approved the study according to the principles of the Declaration of Helsinki.(Approved - 2002)

Patients:

65 infants who were admitted to Pediatric A- a general pediatric ward, in Schneider Children's Medical Center because of bronchiolitis during winter in two consecutive years 2004-2005.

The inclusion criteria were: Full term previously healthy Infants, ages 1-12 months, after informed consent was signed with clinical presentation of mild to moderate bronchiolitis according to a clinical score .Exclusion criteria were as follows: prematurity, congenital lung or cardiac disease, infants who had past hospitalization due to respiratory illness and severe bronchiolitis (score>7 with a range scale 0-10).

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Schneider Children's Medical Center, Israel
• Treatments: Ephedrine; Epinephrine; Epinephryl borate; Nasal Decongestants; Pseudoephedrine; Racepinephrine; Xylometazoline

Criteria

Inclusion Criteria:

• Full term previously healthy Infants

• Ages 1-12 months

• After informed consent was signed with clinical presentation of mild to moderate bronchiolitis

Exclusion Criteria:

• Prematurity, congenital lung or cardiac disease

• Infants who had past hospitalization due to respiratory illness and severe bronchiolitis (score >7 with a range scale 0-10)