The Influence of Liraglutide on the Reward Properties of Food: an fMRI Study on Healthy Volunteers
Status:
Completed
Trial end date:
2012-03-01
Target enrollment:
Participant gender:
Summary
Clinical experience has confirmed the anorexic effect of Glucagon-like-peptide 1 (GLP-1)
mimetics in comparison to DPP-4 inhibitors. A possible mechanism of this effect might be
associated with changes in food choices, as suggested by animal studies. It has been shown
that functional magnetic resonance imaging (fMRI) of the brain is a valuable tool in obesity
research and can be used to study the response of several brain regions to the visual
presentation of preferred in comparison to non preferred food items and to non food items The
aim of this study is to search for possible effects of liraglutide in comparison to placebo
on 1. food choices and 2. changes in brain function as evidenced by fMRI in healthy
volunteers.
Findings of this study will help not only to get deeper insight into the mechanism of the
anorexic effect of GLP-1 mimetics, but also into the regulation of food choices per se. In
the future, it is planned to extend the results of this study in normal weight volunteers to
obese diabetic subjects.