The Influence of Perioperative Administration of Dexmedetomidine on Inflammation Response and Postoperative Recovery in Patients Undergoing Robot or Laparoscopic Assisted Gastrectomy

• Status: Completed
• Trial end date: 2019-11-29
• Target enrollment: 0
• Participant gender: All

Summary

Many studies have shown that inflammation has an important effect on the development, progression, and also response to treatment of tumors. Dexmedetomidine is a potent and selective alpha 2 receptor agonist, known to have a sedative, analgesic and immune-controlling effect. The purpose of this study is to investigate the effect of dexmedetomidine during surgery on postoperative inflammatory response and surgical recovery in gastric cancer patients undergoing robot or laparoscopic gastrectomy.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• 1. 20-70 yrs old patients

• 2. Scheduled for robot or laparoscopic gastrectomy

• 3. Body weight under 90kg and BMI under 32

Exclusion Criteria:

• 1. Emergency operation

• 2. Reoperation

• 3. Co-operation with other surgery department

• 4. Co-operation with other organs (except cholecystectomy)

• 5. Patients with history of heart failure (unstable angina, congestive heart failure)

• 6. Patients with history of arrhythmia (specially AV nodal block), ventricular conduction problem

• 7. Patients with history of uncontrolled hypertension (diastolic BP >110mmHg), extremely bradycardia (HR <45 bpm on ECG)

• 8. Patients with history of cerebrovascular disease (cerebral hemorrhage, cerebral ischemia

• 9. Patients who is steroid user

• 10. Patients who is beta blocker user

• 11. Patients with history of liver failure, renal failure, allergic to medicine

• 12. Patients with history of uncontrolled psychiatric disease (PTSD, anxiety, depression)

• 13. Patients who cannot read the consent form (examples: Illiterate, foreigner)

• 14. Patients who withdraw the consent