The Influence of Postoperative Analgesia on Systemic Inflammatory Response and POCD After Femoral Fractures Surgery

• Status: Completed
• Trial end date: 2017-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether epidural levobupivacaine applied for the purpose of post-operative analgesia compared to systemic analgesia with morphine leads to better pain control, stronger suppression of the inflammatory response and the production of inflammatory mediators, faster recovery of patients and consequently less incidence of postoperative cognitive dysfunction (POCD) in elderly patients after surgical treatment of femoral fractures.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Osijek University Hospital
• Treatments: Bupivacaine; Levobupivacaine; Morphine

Criteria

Inclusion Criteria:

• patients age 65 and over

• fracture of the proximal femur

• preoperative assessment American Society of Anesthesiologists(ASA) score I - ASA III

• a written consent of the patient to participate in research

Exclusion Criteria:

• patient non-compliance

• ASA status IV and IV above

• patients younger than 65 years

• dementia, Parkinson's disease, cerebrovascular accident history; simultaneous head injuries,the use of opioids and benzodiazepines longer than a month before the surgery; alcoholism; serious liver disease (class C according to Child-Pugh's classification); severe kidney disease that require dialysis

• result of MMSE test (Mini-Mental State Examination) under 17

• the existence of any contraindications for the implementation of regional anesthesia and one or other form of post-operative analgesia.