The Influence of Sequential Tau Protein and Amyloid Plaque Imaging Changes on Stroke Prognosis and Cognitive Outcome
Status:
Recruiting
Trial end date:
2023-05-31
Target enrollment:
Participant gender:
Summary
Amyloid plaques and tau protein are the landmarks of neurodegeneration in Alzheimer's disease
(AD). On the other hand, it is reported that cerebral ischemia may induce amyloid plaques and
tau protein accumulation. However, it was difficult to in vivo disentangle the complex and
dynamic interactions between AD pathophysiology and cerebral vascular injury in the
development of post-stroke cognitive impairment in the past. With the advent of novel
radiotracers specific to cerebral amyloid plaques and tau protein, we aim to conduct a
prospective multimodal neuroimaging cohort study to investigate the contribution of vascular
injury, amyloid plaques and tau protein to stroke recovery and post-stroke cognitive
impairment.