The Inhibitory Effect of Metformin on Gluconeogenesis in Relation to Polymorphisms in Organic Cation Transporter 1
Status:
Completed
Trial end date:
2012-12-01
Target enrollment:
Participant gender:
Summary
The aim of the study is to evaluate the pharmacodynamic impact of metformin in healthy
Caucasian volunteers with and without single polymorphisms M420del or R61C in OCT1, thus the
study hypothesis is that metformin only affect the hepatic gluconeogenesis in healthy
volunteers with functional OCT1-transporters.