The Lowest Effective Dose of Dexmedetomidine in Attenuating the Hemodynamic Responses During Skull Pin Insertion in Patients Undergoing Elective Craniotomy

• Status: Unknown status
• Trial end date: 2019-03-01
• Target enrollment: 0
• Participant gender: All

Summary

Skull pins are used to immobilize the head during craniotomy. Fixation of skull pins causes acute hemodynamic changes which may affect cerebral autoregulation and hence cerebral blood flow. Therefore, maintenance of stable hemodynamic parameters during skull pin placement under general anesthesia is crucial to ensure adequate cerebral perfusion and prevention of acute rise of intracranial pressure

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Assiut University
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• 120 Adult patients,

• undergoing elective craniotomy

• ASA I and II patients

Exclusion Criteria:

• patients undergoing craniotomy for emergency surgery,

• raised ICP,

• obese patients (body mass index >30 kg/m2 for males and 28 kg/m2 for females),

• patients having systemic comorbidities (cardiac, renal, hepatic, and endocrinal),

• hypertensive patients (including those detected after admission),

• patients undergoing intracranial aneurysm clipping