The Median Effective Dose (ED50) of Paracetamol and Morphine : A Study of Interaction Study

• Status: Completed
• Trial end date: 2011-03-01
• Target enrollment: 0
• Participant gender: All

Summary

The aim of our study is to define the median effective analgesic doses (ED50) of paracetamol, morphine, and their combination and determination the nature of their interaction administered IV for postoperative pain after moderate painful surgery using up-and-down and isobolographic methods.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Procare Riaya Hospital
• Treatments: Acetaminophen; Morphine

Criteria

Inclusion Criteria:

1. ASA physical status І or ІІ

2. Moderately painful surgery patients

3. postoperative pain more than 3 on a numerical pain score (NPS) -

Exclusion Criteria:

1. contraindication to the use of paracetamol and morphine

2. Pregnancy

3. age younger than 18 yr

4. patient weight less 65kg

5. intra-operative regional anesthesia,

6. intra-operative administration of analgesics other than fentanyl,

7. postoperative pain less than 3 on a numerical pain score (NPS)