The Montefiore Metoclopramide Study

• Status: Completed
• Trial end date: 2008-02-01
• Target enrollment: 0
• Participant gender: All

Summary

Metoclopramide is a dopamine antagonist frequently used for the treatment of nausea, vomiting, and migraine headaches in Emergency Departments. However, little research has focused on the optimal dose of metoclopramide for treatment of nausea in the emergency department. We propose a randomized, double-blind, placebo controlled trial to investigate the optimal dose of metoclopramide for treatment of nausea.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Montefiore Medical Center
• Treatments: Diphenhydramine; Metoclopramide; Promethazine

Criteria

Inclusion Criteria:

• primary or secondary complaints of nausea/vomiting

• age 21-65

Exclusion Criteria:

• pregnancy

• use of anti-histamine or dopamine antagonist as outpatient and/or within last 24 hours of presentation

• previous adverse reaction to study medications

• use of opioid medications prior to study start time within that ED visit