The Mortality and Changes in Quality of Life of Patients Suffering From SAH With Different Hydration Strategies
Status:
Completed
Trial end date:
2013-10-01
Target enrollment:
Participant gender:
Summary
Purpose:
- Vasospasm and secondary ischemia following subarachnoidal hemorrhage considerably affect
the clinical outcome. The purpose of this study is to determine whether crystalloid (Lactated
Ringer's solution) or colloid (hydroxyethyl starch) intravenous infusion is more effective in
the treatment of subarachnoid hemorrhage (SAH)
Treatment:
- Patients are randomly divided into two groups. Depending on the blood pressure of the
patients the members of the first group receive 15-50 ml/kg Lactated-Ringer's solution daily
as part of the treatment, while the others 15 ml/kg Lactated-Ringer's and 15-50 ml/kg
hydroxyethyl starch solution daily.
Measurements:
- Neurological status of patients will be determined by the NIH Stoke Scale Score and the
Glasgow Coma Scale (GCS) on a daily basis.
- The mid-term survival and quality of life are evaluated with Barthel Index and Glasgow
Outcome Scale (GOS) 14 and 30 days following admission to our clinic.
Hypothesis:
-The prevalence of vasospasms, the mortality rate and the medium-term quality of life
following subarachnoid hemorrhage is improved if patients are treated with intravenous
colloid (hydroxyethyl starch) infusion compared to intravenous crystalloid infusion.