The Neural Mechanisms of Anesthesia and Human Consciousness (Part 6)
Status:
Completed
Trial end date:
2017-03-13
Target enrollment:
Participant gender:
Summary
Positron Emission Tomography (PET), Magnetic Resonance Imaging (MRI) and
electroencephalography (EEG) studies will be carried out to reveal the neural correlates of
consciousness. Consciousness of the subjects will be manipulated with anesthetic agents
dexmedetomidine, propofol, S-ketamine and sevoflurane. One-hundred-and-sixty (160) healthy
male subjects will be recruited to receive EC50 concentration of the anesthetic (40
dexmedetomidine, 40 propofol, 20 S-ketamine, 40 sevoflurane) or placebo (20) while being
imaged for cerebral metabolic rate of glucose (CMRglu). Also genetic, immunological and
metabolomics samples will be taken and analysed to find possible genetic factors explaining
the variability in drug response and to find chemical fingerprints of acute drug effect.
Phase:
Phase 4
Details
Lead Sponsor:
University of Turku
Collaborators:
Helsinki University University of California, Irvine University of Helsinki University of Michigan Yale University