The Oligonucleotide Chip Analysis for Allergic Rhinitis Treatment in Herbal Plaster and Acupuncture
Status:
Completed
Trial end date:
2011-08-01
Target enrollment:
Participant gender:
Summary
Using Oligonucleotide Chip Analysis, investigators compared gene expression levels in
allergic rhinitis patients before and after a series of acupoint herbal plaster and
Acupuncture treatment.
In the first year, Twenty-three participants with persistent allergic rhinitis each received
four acupoint herbal plaster treatments, applied using the moxibustion technique, and
clinical outcomes were evaluated using the Rhinitis Quality of Life Questionnaire (RQLQ).
Peripheral blood samples were analyzed using an ImmunoCAP Phadiatop test, and patients were
classified as phadiatop (Ph)-positive or -negative. Microarray results were examined for
genes that were differentially expressed between (1) Ph-positive and -negative patients
treated with herbal paste; and (2) before and after herbal paste treatment in the Ph-positive
patient group.
In the second year, Twenty-seven participants with persistent allergic rhinitis each received
four acupoint herbal plaster treatments and 8 courses of acupuncture treatment over 4 weeks
in the same time.