The Optimal Dose of Sevoflurane Via Anaconda® in Post-operative Patient Underwent Head & Neck Surgery

• Status: Completed
• Trial end date: 2019-03-31
• Target enrollment: 0
• Participant gender: All

Summary

Sedation in the ICUs is very common. There is no ideal sedative yet, so research has been conducted to replace propofol and midazolam, which are the most commonly used sedatives in ICUs, by inhalation anesthetics. The investigators will sedate the patients who undergo head & neck surgery with tracheostomy for several days using sevoflurane, a kind of inhalation agent, via anesthetic conserving device.

The objective of this study is to confirm the end-tidal sevoflurane concentration for inducing moderate sedation (RASS -2~-3). In addition, the investigators compare the volatile sedation with the IV(intravenous) sedation to see if the volatile sedation could reduce the amount of post-operative opioid consumption.

• RASS: Richmond Agitation-Sedation Scale

• RASS: Richmond Agitation-Sedation Scale

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Yonsei University
• Treatments: Anesthetics; Propofol; Sevoflurane

Criteria

Inclusion Criteria:

• Patients who needs sedation in the ICU for several days after head & neck surgery

• ASA class I~III

• Adult patients over 20 years old

• Patients who can read and understand the informed consent

Exclusion Criteria:

• Patients who do not agree to participate in the study

• Past history or Family history of malignant hyperthermia

• End stage renal disease (eGFR<30 or dialysis)

• Moderate to severe liver disease (AST, ALT > 200IU/L)

• Pregnant women

• Patients who cannot read and understand the informed consent