The Outcomes of Hypertension in Obese Versus Non-obese Pregnant Women
Status:
Not yet recruiting
Trial end date:
2025-10-01
Target enrollment:
Participant gender:
Summary
Hypertensive disorders of pregnancy, include pre-existing and gestational hypertension,
preeclampsia, and eclampsia, it complicates up to 10% of pregnancies and represents a
significant cause of maternal and perinatal morbidity and mortality. Following the "National
High Blood Pressure Education Program Working Group on High Blood Pressure in Pregnancy"
recommendation is currently a systolic blood pressure (SBP) ⩾ of 140 mmHg and diastolic blood
pressure (DBP) ⩾ of 90 mmHg. The diagnosis generally requires two separate measurements.
Accepted across international guidelines are the following four categories:
Chronic/pre-existing hypertension (Hypertension discovered preconception or prior to 20 weeks
gestation), Gestational hypertension (Hypertension that appears de novo after 20 weeks
gestation and normalizes after pregnancy), Preeclampsia-eclampsia (De novo hypertension after
20 weeks' gestation accompanied by proteinuria, other features of maternal organ dysfunction
or uteroplacental dysfunction), Chronic/pre-existing hypertension with superimposed
preeclampsia-eclampsia. Over the past 2 decades, extensive epidemiologic studies have clearly
established that obesity is a major risk for gestational hypertension and preeclampsia. The
risk of preeclampsia typically doubles with each 5-7 kg/m2 increase in pre-pregnancy. The
mechanisms have only been partially explored; increased cytokine-mediated inflammation and
oxidative stress, increased shear stress, dyslipidemia, and increased sympathetic activity1
have all been proposed as possible pathways. Few studies have examined the relationship
between pre-pregnancy BMI, gestational weight gain (GWG), and the risk of preeclampsia. So,
our study aims to evaluate the adverse maternal and fetal outcomes related to hypertension in
obese and non-obese pregnant women.