The PRIME Study: A Randomized, Controlled, Prospective Study

• Status: Recruiting
• Trial end date: 2021-08-27
• Target enrollment: 0
• Participant gender: All

Summary

To investigate the outcomes of patients undergoing bilateral RLE surgery with treatment of dexamethasone intracanilicular insert compared to topical standard care steroid. Desiged to look at patient preference comparing the insert to drops and will also look at patient outcomes including inflammatin and risk of cystoid macular edema post-operatively.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Vance Thompson Vision - MT
• Treatments: Prednisolone

Criteria

Inclusion Criteria:

• Any adult patient who is planned to undergo bilateral RLE surgery with BCVA 20/30 or better

• Willing and able to comply with clinic visits and study related procedures

• Willing and able to sign the informed consent form

Exclusion Criteria:

• Patients under the age of 22 or above the age of 75

• Patients who are pregnant (must be ruled out in a women of child-bearing age with pregnancy test).

• Patients with active infectious ocular or extraocular disease.

• Patients actively treated with local or systemic immunosuppression including systemic corticosteriods

• Paitents with know hypersensitivity to Dexamethasone

• Patients with severe disease that warrants critical attentino, deemed unsafe for the study by the investigator

• Patients with a history of ocular inflammation or macular edema

• Patients with allergy or inability to receive intracameral antibiotic

• Patients on systemic non-steroidal anti-inflammatory drugs (NSAID) grater than 1,200 mg/day

• Patient with a corticosteriod implant (i.e. Ozurdex).

• Patient with corneal pathology which pre-disposes them to unsatisfactory outcomes