The Pathogenesis of Chronic Diarrhoea After Treatment for Cancer in Cecum and the Ascending Colon

• Status: Completed
• Trial end date: 2021-05-26
• Target enrollment: 0
• Participant gender: All

Summary

Many patients suffer from chronic diarrhoea after surgical treatment for cancer in the right side of the colon.

The investigators' main hypothesis is that colon cancer patients with chronic diarrhoea have a higher risk of bile acid malabsorption compared with colon cancer patients without diarrhoea.

The investigators also expect that a part of the cases of bile acid malabsorption is caused by underlying bacterial overgrowth in the small bowel.

The investigators assume that patients with severe bile acid malabsorption have a lower value of FGF19 in the blood compared to patients with moderate or none bile acid malabsorption.

Furthermore, it is assumed that patients with chronic diarrhoea and documented bile acid malabsorption after surgical treatment for right-sided colon cancer will get improved bowel function when treated with a bile acid binder, or antibiotics in case of bacterial overgrowth.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Aarhus
• Collaborators: Danish Cancer Society; GE Healthcare
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Bile Acids and Salts

Criteria

Inclusion Criteria:

• Primary adenocarcinoma in cecum or the ascending colon

• Right-sided hemicolectomy

• Understanding, speaking and reading Danish

Exclusion Criteria:

• Previous major gastrointestinal, urological or gynaecological surgery or oncological treatment

• Radiation therapy

• Recurrence of colon cancer

• Metastasis

• Permanent stoma

• Pregnancy

• Reduced cognitive level that makes it plausible that the patient do not understand the study or is not capable of participation