The Pharmacodynamic/Pharmacokinetic Interaction of Tipranavir and Ritonavir With Loperamide in Healthy Volunteers
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
The objective of the study was to determine if the co-administration of loperamide (LOP) with
tipranavir (TPV), ritonavir (RTV), or TPV plus RTV (TPV/r) caused a clinically significant
change in the respiratory response to carbon dioxide (CO2), defined as a 10% decrease in the
area under the pharmacodynamic effect/time curve or at least a 25% decrease in at least one
pharmacodynamic time point.