The Pharmacodynamics of Doripenem Between 4-hour and 1-hour Infusion in Patients With Ventilator-associated Pneumonia
Status:
Completed
Trial end date:
2011-10-01
Target enrollment:
Participant gender:
Summary
This is prospective and randomized study to assess the pharmacodynamics (t>MIC) of 0.5 g
every 8 h of doripenem in patients with VAP following administration by a 4 h infusion or 1 h
infusion.
Clinical and laboratory data such as Age,Sex, Body weight, Electrolyte, Vital signs, APACHE
II score, BUN, Cr, Blood culture will be collected.
Twelve patients will be enrolled in this study. After completion of the doripenem therapy for
3 days in this study, all patients will receive other sensitive antibiotics to eradicate
their bacterial infections.
Doripenem pharmacokinetic study will be carried out during the doripenem therapy. Blood
samples (approximately 2 ml) in group " 0.5 g of doripenem with 4 h infusion every 8 h
regimen" will be obtained by direct venepuncture at the following time: 0, 0.5, 1, 2, 3, 4,
4.5, 5, 6, 7 and 8 h after 7th dose of doripenem.
Blood samples (approximately 2 ml) in group " 0.5 g of doripenem with 1 h infusion every 8 h
regimen" will be obtained by direct venepuncture at the following time: 1, 1.5, 2, 4, 5, 6, 7
and 8 h after 7th dose of doripenem.
The doripenem assays by method of Ikeda K et al. (J Chromatogr B, 2008) will be performed.
Concentration of doripenem in plasma will be simulated in Monte Carlo technique (Computer
model) to get PK/PD index (40%T>MIC) and reported to % PTA (Probability Target Attainment)
and %CFR (Cumulative Faction Response)