The Pharmacokinetics of Zidovudine and Oxazepam Alone and in Combination in the HIV-Infected Patient
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
To determine if a pharmacokinetic (blood level) interaction exists between zidovudine (AZT)
and oxazepam in the HIV-infected patient. Benzodiazepines (such as oxazepam) are among the
most frequently prescribed class of drugs and are commonly used therapeutically for patients
with chronic disease. This study is important because of the potential for toxicity resulting
from a reaction between AZT and benzodiazepines and the likelihood of frequent use of the
combination of these drugs in patients with HIV infection.
Phase:
Phase 1
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)