The Pharmacokinetics of a Single Large Dose of Vitamin D3
Status:
Completed
Trial end date:
2007-03-01
Target enrollment:
Participant gender:
Summary
When people eat a meal, some, but not all of the calcium in that meal is absorbed, that is,
moved into the bloodstream. When the skin is exposed to sunlight during summer months,
Vitamin D is made there and then modified into more active forms by the liver and kidneys.
These more active forms of Vitamin D improve calcium absorption. Many adults living in the
U.S. have little or no sun exposure and are low in Vitamin D. A single dose of 100,000 IU of
Vitamin D3 has been used both as empiric treatment for Vitamin D deficiency as well as in
controlled trials without risk of raising blood calcium to dangerous levels.This study is to
determine the serum levels of Vitamin D and 25-hydroxyvitamin D (vitamin D after it has been
modified by the liver) that can be expected when Vitamin D3 is given as a single oral dose of
100,000 IU.
Phase:
N/A
Details
Lead Sponsor:
Creighton University
Collaborator:
Procter and Gamble
Treatments:
Cholecalciferol Ergocalciferols Vitamin D Vitamins