The Phosphodiesterase 5 Inhibitor Tadalafil as an Adjunct to Antidepressants in Major Depressive Disorder Patients
Status:
Recruiting
Trial end date:
2022-12-31
Target enrollment:
Participant gender:
Summary
Antidepressant-like effects of tadalafil to its ability to modulate transduction pathways
responsible for neuroplasticity. Treatment with tadalafil was shown to be PKG-dependent and
lead to increased expression of cGMP, pCREB, BDNF and VGF in the hippocampus and prefrontal
cortex (PFC), brain areas relevant to mood disorders pathophysiology. Low-dose tadalafil
improved both depressive symptoms in patients with erectile dysfunction.