The Placebo Effect May Involve Modulating Drug Bioavailability

• Status: Completed
• Trial end date: 2013-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The total effect of a medication is the sum of its drug effect, placebo effect (meaning response of placebo), and their interaction. Current interpretation of clinical trials (the gold standard of evidence-based-medicine) assumes no interaction, and the mechanism(s) underlying such interaction have not been fully explored. One possibility is that the placebo effect may modulate drug bioavailability. Using caffeine as a model drug, we have recently shown that the placebo effect of caffeine ingestion prolongs caffeine half life. Due to the novelty of this finding and its important clinical practice and clinical research implications, it needs to be confirmed in another set of subjects and extended to additional drugs.

The results of the study are expected to further our understanding of the mechanism of action of a widely used medical intervention, i.e., placebo. The results will be important for both clinical practice and clinical research.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: King Faisal Specialist Hospital & Research Center
• Treatments: Acetaminophen; Caffeine; Cephalexin; Ibuprofen

Criteria

Inclusion Criteria:

• Having no evidence of clinically important deviation from normal health as indicated by medical history, vital signs, and clinical laboratory tests.

• Acceptance to abstain from taking any medication other than birth control pills (including over-the-counter drugs) for at least 1 week prior to, and during the study; and from smoking and taking alcohol or caffeine or related xanthenes-containing beverages or food for 48 hours before and throughout each study period.

• Having good peripheral venous access.

• For the caffeine study, habitual daily caffeine intake should be 100-300 mg.

Exclusion Criteria:

• Women should be non-pregnant and non-lactating. For menstruating women, the study will be conducted 5 to 19 days after the last menstrual period and a urine pregnancy test will be performed.

• Should not have history of hypersensitivity to the drug to be tested or to its related compounds.

• Body Mass Index (BMI) should be less than 35 kg/m2.