The Possible Protective Role of Omeprazole Against Oxaliplatin Induced Neuropathy in Cancer Patients
Status:
Not yet recruiting
Trial end date:
2023-12-01
Target enrollment:
Participant gender:
Summary
Oxaliplatin(OXA) chemotherapy protocols are used in treatment of cancers like colorectal
(CRC) and pancreatic cancer. OXA causes peripheral neuropathy which is considered treatment
limiting factor. In recent studies, it shows that omeprazole(OME) has antioxidant effect and
can inhibit organic cation transporter 2 (OCT2) in kidney. So OME can protect against
peripheral neuropathy induced by OXA through oxidative stress . Also OME activates
extracellular-signal-regulated kinase(ERK) / mitogen activated protein kinase ( MAPK)
pathway, so improves demyelinating symptoms.